Name: Ini1 Polyclonal Antibody
SKU: WP15771
Price: 268 USD
Availability: InStock

Product details

Background:

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015],

Specifications

Target	INI-1
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	45kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:10000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthetic peptide from human protein at AA range: 331-380
Sequence
Specificity	The antibody detects endogenous Ini1 protein
Gene Name	SMARCB1 BAF47 INI1 SNF5L1
Protein Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Other Name	BAF47; / BRG1-associated factor 47; / hSNF5; / INI1; / Integrase interactor 1 protein; / Malignant rhabdoid tumor suppressor; / RDT; / RTPS1; / Sfh1p; / SMARCB1; / SNF5 homolog; / SNF5_HUMAN; / SNF5L1; / Snr1; / Sucrose nonfermenting yeast homolog like 1; / SWI/SNF complex component SNF5; / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; / SWI10; / Transcription factor TYE4; / Transcription regulatory protein SNF5; / TYE4
Species	Human
Gene ID-1	6598
Uniprot	Q12824,
Species.1	Mouse
Gene ID-2	20587
Uniprot.1	Q9Z0H3
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015],
Cellular Localization	Nucleus.
Tissue Expression	Bra
Signaling_pathway	Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Genetic Information Processing >> Chromosome >> ATP-dependent chromatin remodeling
Research Areas	>>Viral life cycle - HIV-1; / >>Thermogenesis; / >>Hepatocellular carcinoma
Function	Disease:Defects in SMARCB1 are a cause of rhabdoid tumor (RDT) [MIM:609322]; also called malignant rhabdoid tumor (MRT). Tumor suppressor. Inactivated in rhabdoid tumors. Rhabdoid tumors are a highly malignant group of neoplasms that usually occur in early childhood. SMARCB1/INI1 is also frequently inactivated in epithelioid sarcomas.,Disease:Defects in SMARCB1 are a cause of schwannomatosis [MIM:162091]; also called congenital cutaneous neurilemmomatosis. Schwannomas are benign tumors of the peripheral nerve sheath that usually occur singly in otherwise normal individuals. Multiple schwannomas in the same individual suggest an underlying tumor-predisposition syndrome. The most common such syndrome is NF2. The hallmark of NF2 is the development of bilateral vestibular-nerve schwannomas; but two-thirds or more of all NF2-affected individuals develop schwannomas in other locations, and dermal schwannomas may precede vestibular tumors in NF2-affected children. There have been several reports of individuals with multiple schwannomas who do not show evidence of vestibular schwannoma. Clinical report suggests that schwannomatosis is a clinical entity distinct from other forms of neurofibromatosis.,Function:Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1. Involved in activation of CSF1 promoter. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF5 family.,subunit:Component of the BAF (hSWI/SNF) complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Binds directly with SMARCC1/BAF155 and SMARCC2/BAF170, and these three proteins bind SMARCA4/BRG1. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Binds to double-stranded DNA. Interacts with MYK and MAEL. Interacts with PPP1R15A. Binds tightly to the human immunodeficiency virus-type 1 (HIV-1) integrase in vitro and stimulates its DNA-joining activity. Interacts with human papillomavirus 18 E1 protein to stimulates its viral replication. Interacts with Epstein-Barr virus protein EBNA-2.,
RRID

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Ini1 Polyclonal Antibody

Product details

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Ini1 Polyclonal Antibody

Product details

Specifications

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