INPP5J Polyclonal Antibody
Ucallm_WP12834-50
Price range: $268.00 through $328.00
Product details
Background:
catalytic activity:1D-myo-inositol 1, 3, 4, 5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1, 3, 4-trisphosphate + phosphate., catalytic activity:D-myo-inositol 1, 4, 5-trisphosphate + H(2)O = myo-inositol 1, 4-bisphosphate + phosphate., domain:The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein., function:Inositol 5-phosphatase, which converts inositol 1, 4, 5-trisphosphate to inositol 1, 4-bisphosphate. Also converts phosphatidylinositol 4, 5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate to inositol 1, 3, 4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles., PTM:Phosphorylated at Ser/Thr residues., similarity:Belongs to the inositol-1, 4, 5-trisphosphate 5-phosphatase type II family., subcellular location:Predominantly localized to membrane ruffles.,
Specifications
| Size | 50μL/100μL |
| Target | INPP5J |
| Reactivity | Human, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 107kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from INPP5J . at AA range: 850-930 |
| Specificity | INPP5J Polyclonal Antibody detects endogenous levels of INPP5J protein. |
| Gene Name | INPP5J |
| Protein Name | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A |
| Other Name | INPP5J; / PIB5PA; / PIPP; / Phosphatidylinositol 4; / 5-bisphosphate 5-phosphatase A; / Inositol polyphosphate 5-phosphatase J |
| Species | Human |
| Gene ID | 27124 |
| Uniprot | Q15735, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P59644, |
| Species.2 | Rat |
| Gene ID.2 | 171088 |
| Uniprot.2 | Q9JMC1 |
| Cellular Localization | Cytoplasm . Predominantly localized to membrane ruffles. . |
| Tissue Expression | Brain,Cerebellum,Heart, |
| Signaling_pathway | |
| Research Areas | >>Inositol phosphate metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.,Catalytic activity:D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.,Domain:The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.,Function:Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles.,PTM:Phosphorylated at Ser/Thr residues.,similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.,subcellular location:Predominantly localized to membrane ruffles., |
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