SKU: WP12957 Categories: ,

Kv3.4 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12957-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010],

Specifications

Size50μL/100μL
TargetKv3.4
ReactivityHuman, Mouse, Monkey
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)70kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human KCNC4. AA range:1-50
SpecificityKv3.4 Polyclonal Antibody detects endogenous levels of Kv3.4 protein.
Gene NameKCNC4
Protein NamePotassium voltage-gated channel subfamily C member 4
Other NameKCNC4; / Potassium voltage-gated channel subfamily C member 4; / KSHIIIC; / Voltage-gated potassium channel subunit Kv3.4
SpeciesHuman
Gene ID3749
UniprotQ03721,
Species.1Mouse
Gene ID.199738
Uniprot.1Q8R1C0
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionBrain,
Signaling_pathway
Research Areas
FunctionDomain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,Function:This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,PTM:Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:Homotetramer (Probable). Heterotetramer of potassium channel proteins.,
Please login to post questions
Back to Top
Product has been added to your cart