LSHB Polyclonal Antibody
Ucallm_WP3298-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | LSHB |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 15kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | LSHB Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | LHB |
| Protein Name | Lutropin subunit beta (Lutropin beta chain) (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta) |
| Other Name | |
| Species | Human |
| Gene ID | 3972 |
| Uniprot | P01229, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O09108, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P01230 |
| Cellular Localization | Secreted. |
| Tissue Expression | Pituitary gland. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> GnRH signaling pathway;Organismal Systems >> Endocrine system >> Prolactin signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>GnRH signaling pathway; / >>Ovarian steroidogenesis; / >>Prolactin signaling pathway; / >>GnRH secretion |
| Function | Disease:Defects in LHB are a cause of hypogonadism [MIM:152780]. Hypogonadism is characterized by infertility and pseudohermaphroditism.,Function:Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.,online information:Luteinizing hormone entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the glycoprotein hormones subunit beta family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,tissue specificity:Pituitary gland., |
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