Name: MAO-A Polyclonal Antibody
SKU: WP13067
Price: 268 USD
Availability: InStock

MAO-A Polyclonal Antibody

Ucallm_WP13067-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP13067-100

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Product details

Background:

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012],

Specifications

Size	50μL/100μL
Target	MAO-A
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	61kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human MAO-A. AA range:298-347
Specificity	MAO-A Polyclonal Antibody detects endogenous levels of MAO-A protein.
Gene Name	MAOA
Protein Name	Amine oxidase [flavin-containing] A
Other Name	MAOA; / Amine oxidase [flavin-containing] A; / Monoamine oxidase type A; / MAO-A
Species	Human
Gene ID	4128
Uniprot	P21397,
Species.1	Mouse
Gene ID.1	17161
Uniprot.1	Q64133,
Species.2	Rat
Gene ID.2
Uniprot.2	P21396
Cellular Localization	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side .
Tissue Expression	Heart, liver, duodenum, blood vessels and kidney.
Signaling_pathway	Organismal Systems >> Nervous system >> Dopaminergic synapse;Human Diseases >> Neurodegenerative disease >> Parkinson disease
Research Areas	>>Glycine, serine and threonine metabolism; / >>Arginine and proline metabolism; / >>Histidine metabolism; / >>Tyrosine metabolism; / >>Phenylalanine metabolism; / >>Tryptophan metabolism; / >>Drug metabolism - cytochrome P450; / >>Metabolic pathways; / >>Serotonergic synapse; / >>Dopaminergic synapse; / >>Parkinson disease; / >>Cocaine addiction; / >>Amphetamine addiction; / >>Alcoholism
Function	Catalytic activity:RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).,cofactor:FAD.,Disease:Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.,Function:Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.,mass spectrometry: PubMed:11812236,online information:Monoamine oxidase entry,similarity:Belongs to the flavin monoamine oxidase family.,subunit:Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.,tissue specificity:Heart, liver, duodenum, blood vessels and kidney.,