Product details
Background:
MCM10 rabbit pAb
Ucallm_WP17907-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | MCM10 |
| Reactivity | Human, Mouse |
| Applications | IHC, WB |
| MW(Calculated) | 96kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human N-ternal MCM10 |
| Specificity | This antibody detects endogenous levels of MCM10 at Human, Mouse |
| Gene Name | MCM10 PRO2249 |
| Protein Name | Protein MCM10 homolog (HsMCM10) |
| Other Name | Protein MCM10 homolog; / HsMCM10 |
| Species | Human |
| Gene ID | 55388 |
| Uniprot | Q7L590, |
| Species.1 | Mouse |
| Gene ID.1 | 70024 |
| Uniprot.1 | Q0VBD2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli. |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 . |
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