Price range: $268.00 through $328.00
Background:
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],
| Size | 50μL/100μL |
| Target | MOF |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 52kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 14F7 |
| Immunogen | Purified recombinant fragment of human MOF expressed in E. Coli. |
| Specificity | MOF Monoclonal Antibody detects endogenous levels of MOF protein. |
| Gene Name | KAT8 |
| Protein Name | Histone acetyltransferase KAT8 |
| Other Name | KAT8; / MOF; / MYST1; / PP7073; / Histone acetyltransferase KAT8; / Lysine acetyltransferase 8; / MOZ; / YBF2/SAS3, SAS2 and TIP60 protein 1; / MYST-1; / hMOF |
| Species | Human |
| Gene ID | 84148 |
| Uniprot | Q9H7Z6 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Chromosome . |
| Tissue Expression | Brain,Embryo,Heart,Uterus, |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,Function:Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM.,similarity:Belongs to the MYST (SAS/MOZ) family.,similarity:Contains 1 C2HC-type zinc finger.,similarity:Contains 1 chromo domain.,subunit:Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/MYST1, MSL1/hampin, MSL2L1 and MSL3L1. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain., |
