Myeloperoxidase [MPO] [ABT-MPO] mouse mAb
Ucallm_WM1434-50
Price range: $268.00 through $328.00
Product details
Background:
Myeloperoxidase (MPO) is an important enzyme in the process of phagocytosis and lysis of exosomes by granulocytes. It is a specific marker of bone marrow cells. MPO is strongly expressed in normal lymphoid tissues and various myeloid cell hyperplasia, but not in erythroid precursors, lymphoid cells, prokaryotic cells, mast cells, plasma cells, various epithelial tumors and sarcomas. It is mainly used for the differential diagnosis of myeloid cell tumor and lymphoid cell tumor.
Specifications
| Size | 50μL/100μL |
| Target | Myeloperoxidase |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 84kD |
| MW(Observed) | 84kD,60kD |
| Host Species | Mouse |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM-MPO |
| Immunogen | Synthesized peptide derived from human protein. AA range:350-450 |
| Specificity | The antibody can specifically recognize human Myeloperoxidase protein. |
| Gene Name | MPO |
| Protein Name | Myeloperoxidase(MPO) |
| Other Name | 84 kDa myeloperoxidase; / 89 kDa myeloperoxidase; / EC1.11.2.2; / fj80f04; / MPO; / mpx; / myeloid-specific peroxidase; / Myeloperoxidase; / Myeloperoxidase heavy chain; / Myeloperoxidase light chain; / PERM_HUMAN; / wu:fj80f04 |
| Species | Human |
| Gene ID | 4353 |
| Uniprot | P05164 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Leukemia,Leukocyte,Liver,Plasma,Saliva, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia |
| Research Areas | >>Drug metabolism - other enzymes; / >>Phagosome; / >>Neutrophil extracellular trap formation; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia |
| Function | Catalytic activity:Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.,Catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,Disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.,Function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.,online information:MPO mutation db,online information:Myeloperoxidase entry,similarity:Belongs to the peroxidase family. XPO subfamily.,subunit:Tetramer of two light chains and two heavy chains., |
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