Product details
Background:
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- Please choose product options by visiting ASGL1 rabbit pAb.
SHANK1 rabbit pAb
Ucallm_WP6871-50
Price range: $268.00 through $328.00
Specifications
| Target | SHANK1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 238kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SHANK1 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of SHANK1 at Human, Mouse,Rat |
| Gene Name | SHANK1 |
| Protein Name | SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 50944 |
| Uniprot | Q9Y566, |
| Species.1 | Mouse |
| Gene ID-2 | 243961 |
| Uniprot.1 | D3YZU1, |
| Species.2 | Rat |
| Gene ID-3 | 78957 |
| Uniprot.2 | Q9WV48 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Cytoplasm . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Colocalizes with alpha-latrotoxin receptor 1. . |
| Tissue Expression | Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Glutamatergic synapse |
| Research Areas | |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| RRID |
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