Price range: $268.00 through $328.00
Background:
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011],
| Size | 50μL/100μL |
| Target | SOAT1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SOAT1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STAT |
| Protein Name | Sterol O-acyltransferase 1 (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) |
| Other Name | |
| Species | Human |
| Gene ID | 6646 |
| Uniprot | P35610, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61263, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | O70536 |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein . |
| Tissue Expression | Macrophage,Placenta, |
| Signaling_pathway | |
| Research Areas | >>Steroid biosynthesis; / >>Cholesterol metabolism |
| Function | Catalytic activity:Acyl-CoA + cholesterol = CoA + cholesterol ester.,Disease:Accumulation of insoluble cholesterol esters in macrophages and smooth muscle is a characteristic feature of early lesions of atherosclerotic plaque.,Function:Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.,induction:Highly activated by the presence of cholesterol.,similarity:Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.,subunit:May form homo- or heterodimers., |
