SKU: WP14584 Categories: ,

SRp55 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14584-100
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Product details

Background:

The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010],

Specifications

Size50μL/100μL
TargetSRp55
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)40kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from SRp55 . at AA range: 30-110
SpecificitySRp55 Polyclonal Antibody detects endogenous levels of SRp55 protein.
Gene NameSRSF6
Protein NameSerine/arginine-rich splicing factor 6
Other NameSRSF6; / SFRS6; / SRP55; / Serine/arginine-rich splicing factor 6; / Pre-mRNA-splicing factor SRP55; / Splicing factor; / arginine/serine-rich 6
SpeciesHuman
Gene ID6431
UniprotQ13247
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Nucleus speckle .
Tissue ExpressionBrain,Colon,Epithelium,Placenta,
Signaling_pathway
Research Areas>>Spliceosome; / >>Herpes simplex virus 1 infection
FunctionFunction:Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.,PTM:Extensively phosphorylated on serine residues in the RS domain.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Binds SFRS12.,
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