Price range: $288.00 through $368.00
Background:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | SSH3 Phospho Ser37 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 74kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | phosphate |
| Recommended Dilution Ratio | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized phosho peptide around human SSH3 (Ser37) |
| Specificity | This antibody detects endogenous levels of Human SSH3 (phospho-Ser37) |
| Gene Name | SSH3 SSH3L |
| Protein Name | SSH3 (Ser37) |
| Other Name | Protein phosphatase Slingshot homolog 3; / EC 3.1.3.48; / SSH-like protein 3; / SSH-3L; / hSSH-3L |
| Species | Human |
| Gene ID | 54961 |
| Uniprot | Q8TE77, |
| Species.1 | Mouse |
| Gene ID.1 | 245857 |
| Uniprot.1 | Q8K330, |
| Species.2 | Rat |
| Gene ID.2 | 365396 |
| Uniprot.2 | Q5XIS1 |
| Cellular Localization | Cytoplasm, cytoskeleton . Nucleus . |
| Tissue Expression | Cerebellum,Epithelium,Ovarian carcinoma,Uterus, |
| Signaling_pathway | Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton |
| Research Areas | >>Axon guidance; / >>Regulation of actin cytoskeleton |
| Function | Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.,miscellaneous:Tyrosine phosphatase activity has not been demonstrated for this protein to date.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Does not bind to, or colocalize with, filamentous actin., |
