Name: TDG Polyclonal Antibody
SKU: WP14723
Price: 268 USD
Availability: InStock

TDG Polyclonal Antibody

Ucallm_WP14723-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP14723-100

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Product details

Background:

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	TDG
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	46kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human TDG. AA range:31-80
Specificity	TDG Polyclonal Antibody detects endogenous levels of TDG protein.
Gene Name	TDG
Protein Name	G/T mismatch-specific thymine DNA glycosylase
Other Name	TDG; / G/T mismatch-specific thymine DNA glycosylase; / Thymine-DNA glycosylase
Species	Human
Gene ID	6996
Uniprot	Q13569,
Species.1	Mouse
Gene ID.1
Uniprot.1	P56581
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Colon,Lung,Pooled,Thymus,
Signaling_pathway
Research Areas	>>Base excision repair
Function	Function:In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.,PTM:Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA.,similarity:Belongs to the TDG/mug DNA glycosylase family.,

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TDG Polyclonal Antibody

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TDG Polyclonal Antibody

Product details

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