U-Blot® RNA pol II CTD phospho Ser7 Monoclonal Antibody
UcallM
$999.00
Product details
Background:SRF (serum response factor) is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5′ of the site of transcription initiation of some genes (such as FOS). This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).
Specifications
| Target | -- |
| Reactivity | Human |
| Applications | ChIP; ChIP-Seq; WB; IP; IF; ICC |
| MW(Calculated) | 240 kDa |
| Host Species | Rat |
| Isotype | IgG1 |
| Recommended Dilution Ratio | Applications Validated by Active Motif: ChIP: 5-10 µg per ChIP ChIP-Seq: 5-10 µg each |
| Formulation | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| Purification | Protein G Chromatography |
| Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
| Concentration | -- |
| Clonality | Monoclonal |
| Clone Number | 4E12 |
| Immunogen | This RNA pol II CTD phospho Ser7 antibody was raised against a peptide containing the RNA pol II CTD sequence phosphorylated at serine 7. |
| Specificity | -- |
| Gene Name | -- |
| Other Name | RPB1, RPO2, POLR2, POLRA, RPBh1, RPOL2, RpIILS, hsRPB1, hRPB220 |
| Gene ID | -- |
| Cellular Localization | -- |
| Function | -- |
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