Price range: $268.00 through $328.00
Background:The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
| Size | 50μL/100μL |
| Target | SLC40A1 |
| Reactivity | Human, Mouse, Rat, Chicken |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 63kD |
| MW(Observed) | 80kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:200; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1399R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | SLC40A1 FPN1 IREG1 SLC11A3 MSTP079 |
| Protein Name | Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) |
| Other Name | |
| Species | Human |
| Gene ID | 30061 |
| Uniprot | Q9NP59, |
| Species.1 | Mouse |
| Gene ID.1 | 53945 |
| Uniprot.1 | Q9JHI9, |
| Species.2 | Rat |
| Gene ID.2 | 170840 |
| Uniprot.2 | Q923U9 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Localized to the basolateral membrane of polarized epithelial cells. |
| Tissue Expression | Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Ferroptosis |
| Research Areas | |
| Function | Major iron transporter that plays a key role in balancing cellular and systemic iron levels . Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma . |
