SKU: WP14945 Categories: ,

USP11 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14945-100
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Product details

Background:

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetUSP11
ReactivityHuman, Mouse, Rat
ApplicationsIF, WB, ELISA
MW(Calculated)
MW(Observed)105kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIF 1:50-200; WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications;
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from the Internal region of human USP11.
SpecificityUSP11 Polyclonal Antibody detects endogenous levels of USP11 protein.
Gene NameUSP11
Protein NameUbiquitin carboxyl-terminal hydrolase 11
Other NameUSP11; / UHX1; / Ubiquitin carboxyl-terminal hydrolase 11; / Deubiquitinating enzyme 11; / Ubiquitin thioesterase 11; / Ubiquitin-specific-processing protease 11
SpeciesHuman
Gene ID8237
UniprotP51784,
Species.1Mouse
Gene ID.1236733
Uniprot.1Q99K46
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Cytoplasm . Chromosome . Predominantly nuclear (PubMed:12084015, PubMed:15314155). Associates with chromatin (PubMed:20601937, PubMed:20233726). .
Tissue ExpressionBrain,Fetal brain,Muscle,Retina,
Signaling_pathway
Research Areas
FunctionCatalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain.,subunit:Interacts with RANBP9/RANBPM.,
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