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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/VMAT1 Polyclonal Antibody
SKU: WP1015 Categories: ,

VMAT1 Polyclonal Antibody

Ucallm_WP1015-50

Price range: $268.00 through $328.00

SKU: WP1015-100
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Product details

Background:

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008],

Specifications

Size50μL/100μL
TargetVMAT1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)57kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityVMAT1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameSLC18A1 VAT1 VMAT1
Protein NameChromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)
Other Name
SpeciesHuman
Gene ID6570
UniprotP54219,
Species.1Mouse
Gene ID.1
Uniprot.1Q8R090,
Species.2Rat
Gene ID.2
Uniprot.2Q01818
Cellular Localization[Isoform 1]: Cytoplasmic vesicle membrane; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein .; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein .
Tissue ExpressionHighly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).
Signaling_pathwayOrganismal Systems >> Nervous system >> Dopaminergic synapse;Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Human Diseases >> Neurodegenerative disease >> Parkinson disease
Research Areas>>Synaptic vesicle cycle; / >>Serotonergic synapse; / >>Dopaminergic synapse; / >>Parkinson disease; / >>Cocaine addiction; / >>Amphetamine addiction; / >>Alcoholism
FunctionFunction:Involved in the vesicular transport of biogenic amines.,similarity:Belongs to the major facilitator superfamily. Vesicular transporter family.,
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