Product details
Background:
YTHDC2 rabbit pAb
Ucallm_WP6131-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | YTHDC2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 157kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human YTHDC2 |
| Specificity | This antibody detects endogenous levels of YTHDC2 at Human, Mouse |
| Gene Name | YTHDC2 |
| Protein Name | Probable ATP-dependent RNA helicase YTHDC2 (EC 3.6.4.13) |
| Other Name | |
| Species | Human |
| Gene ID | 64848 |
| Uniprot | Q9H6S0, |
| Species.1 | Mouse |
| Gene ID.1 | 240255 |
| Uniprot.1 | B2RR83 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cytoplasm, perinuclear region . |
| Tissue Expression | Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293). |
| Signaling_pathway | |
| Research Areas | |
| Function | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells . Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability . Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease . Required for both spermatogenesis and oogenesis (By similarity). |
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