Product details

Background:
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	IL-8
Reactivity	Human
Applications	IHC, IF
MW(Calculated)
MW(Observed)	11kD
Host Species	Mouse
Isotype	IgG1,kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Monoclonal
Clone Number	13F8
Immunogen	Synthetic C-TERM Peptide of IL-8
Specificity	IL-8 protein detects endogenous levels of IL8
Gene Name	IL8 CXCL8
Protein Name	IL8
Other Name	IL8
Species	Human
Gene ID	3576
Uniprot	P10145
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted.
Tissue Expression	Chronic myeloid leukemia cell,Kidney,Lung,Lung carcinoma,Neutrophil,Periphe
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Immune system >> Chemokine signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Bladder cancer;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas	>>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway; / >>NF-kappa B signaling pathway; / >>Phospholipase D signaling pathway; / >>Cellular senescence; / >>Toll-like receptor signaling pathway; / >>NOD-like receptor signaling pathway; / >>RIG-I-like receptor signaling pathway; / >>IL-17 signaling pathway; / >>Non-alcoholic fatty liver disease; / >>AGE-RAGE signaling pathway in diabetic complications; / >>Alcoholic liver disease; / >>Epithelial cell signaling in Helicobacter pylori infection; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Pertussis; / >>Legionellosis; / >>Yersinia infection; / >>Chagas disease; / >>Malaria; / >>Amoebiasis; / >>Hepatitis B; / >>Human cytomegalovirus infection; / >>Influenza A; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Coronavirus disease - COVID-19; / >>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Bladder cancer; / >>Rheumatoid arthritis; / >>Lipid and atherosclerosis
Function	Function:IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.,online information:Interleukin-8 entry,PTM:Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,subunit:Homodimer.,

Please login to post questions

IL-8 mouse Monoclonal Antibody [13F8]

Product details

Specifications

About Us

Support

Order

Menu

IL-8 mouse Monoclonal Antibody [13F8]

Product details

Specifications

Related products

U-Blot® CDC37 (Phospho Ser13) Rabbit mAb

U-Blot® NLRP3 Rabbit mAb

U-Blot® Ezrin Rabbit mAb

U-Blot® VEGF Receptor 1 Rabbit mAb

U-Blot® HDAC2 Rabbit mAb

U-Blot® BID Rabbit mAb

Customer Reviews

Menu