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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/CD21 [ABT-CD21] mouse mAb
SKU: WM1317 Categories: ,

CD21 [ABT-CD21] mouse mAb

Ucallm_WM1317-50

Price range: $268.00 through $328.00

SKU: WM1317-50
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Product details

Background:
CD21, also known as type 2 complement receptor, is an important marker of B lymphocytes and EB virus receptor. It is a member of the complement activation regulator family. CD21 is mainly distributed in mature B cells, dendritic cells in lymphoid follicles and some T cells. It can promote the proliferation of B cells, participate in immune memory and mediate the transformation of EBV into B cells. It is mainly used for the diagnosis of follicular dendritic cell tumor and the study of immune complement activation regulation.

Specifications

Size50μL/100μL
TargetCD21
ReactivityHuman
ApplicationsIHC, WB, IF, ELISA
MW(Calculated)113kD
MW(Observed)160kD
Host SpeciesMouse
IsotypeIgG1,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMM-CD21
ImmunogenSynthesized peptide derived from human CD21 AA range: 400-500
SpecificityThe antibody can specifically recognize human CD21 protein.
Gene NameCR2 C3DR
Protein NameComplement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)
Other NameC3DR; / CD 21; / CD21; / Complement C3d receptor 2; / Complement C3d receptor; / Complement component; / 3d/Epstein Barr virus; / receptor 2; / Complement receptor type 2; / CR; / Cr2; / CR2_HUMAN; / CVID7; / EBV receptor; / EBV-R; / Epstein Barr virus receptor; / Epstein-Barr virus receptor; / EVBR; / SLEB9
SpeciesHuman
Gene ID1380
UniprotP20023
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembranous
Tissue ExpressionMature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.
Signaling_pathwayOrganismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Complement and coagulation cascades;Organismal Systems >> Immune system >> B cell receptor signaling pathway
Research Areas>>Complement and coagulation cascades; / >>Hematopoietic cell lineage; / >>B cell receptor signaling pathway; / >>Epstein-Barr virus infection
FunctionDisease:Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:610927]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Function:Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.,similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 15 Sushi (CCP/SCR) domains.,tissue specificity:Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.,
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