SKU: WP11679 Categories: ,

CLK4 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11679-100
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Product details

Background:

CDC like kinase 4(CLK4) Homo sapiens The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCLK4
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)65kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human CLK4. AA range:101-150
SpecificityCLK4 Polyclonal Antibody detects endogenous levels of CLK4 protein.
Gene NameCLK4
Protein NameDual specificity protein kinase CLK4
Other NameCLK4; / Dual specificity protein kinase CLK4; / CDC-like kinase 4
SpeciesHuman
Gene ID57396
UniprotQ9HAZ1,
Species.1Mouse
Gene ID.112750
Uniprot.1O35493
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus .
Tissue ExpressionExpressed in liver, kidney, heart, muscle, brain and endothelial cells.
Signaling_pathway
Research Areas>>Legionellosis
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines. Required for the regulation of alternative splicing of MAPT/TAU.,PTM:Autophosphorylates on all three types of residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with UBL5.,tissue specificity:Expressed in liver, kidney, heart, muscle and brain.,
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