SKU: WP0826 Categories: ,

ACOX3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP0826-100
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Product details

Background:

Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008],

Specifications

TargetACOX3
ReactivityHuman, Mouse, Rat, Bovine
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)77kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 480-560
Sequence
SpecificityACOX3 Polyclonal Antibody detects endogenous levels of protein.
Gene NameACOX3 BRCOX PRCOX
Protein NamePeroxisomal acyl-coenzyme A oxidase 3 (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase)
Other Name
SpeciesHuman
Gene ID-18310
UniprotO15254,
Species.1Mouse
Gene ID-2
Uniprot.1Q9EPL9,
Species.2Rat
Gene ID-3
Uniprot.2Q63448
Organism-4
Gene ID-4
SwissProt-4
BackgroundAcyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008],
Cellular LocalizationPeroxisome .
Tissue ExpressionLiver,Uterus,
Signaling_pathwayCellular Processes >> Transport and catabolism >> Peroxisome;Organismal Systems >> Endocrine system >> PPAR signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas>>Fatty acid degradation; / >>beta-Alanine metabolism; / >>alpha-Linolenic acid metabolism; / >>Propanoate metabolism; / >>Biosynthesis of unsaturated fatty acids; / >>Metabolic pathways; / >>Carbon metabolism; / >>Fatty acid metabolism; / >>PPAR signaling pathway; / >>cAMP signaling pathway; / >>Peroxisome; / >>Alcoholic liver disease
FunctionCatalytic activity:Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).,cofactor:FAD.,Function:Oxidizes the CoA-esters of 2-methyl-branched fatty acids.,pathway:Lipid metabolism; peroxisomal fatty acid beta-oxidation.,similarity:Belongs to the acyl-CoA oxidase family.,
RRID
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