SKU: WP2446 Categories: ,

AES Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2446-100
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Product details

Background:

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetAES
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)21kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityAES Polyclonal Antibody detects endogenous levels of protein.
Gene NameAES GRG
Protein NameAmino-terminal enhancer of split (Amino enhancer of split) (Gp130-associated protein GAM) (Protein ESP1) (Protein GRG)
Other Name
SpeciesHuman
Gene ID166
UniprotQ08117,
Species.1Mouse
Gene ID.1
Uniprot.1P63002,
Species.2Rat
Gene ID.2
Uniprot.2P63003
Cellular LocalizationNucleus .
Tissue ExpressionFound predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
Signaling_pathway
Research Areas
FunctionDomain:Lacks the C-terminal WD repeats.,Function:Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state.,similarity:Belongs to the WD repeat Groucho/TLE family.,subunit:Homooligomer and heterooligomer with other family members. Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA. Interacts with PHF12.,tissue specificity:Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.,
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