Product details
Background:
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008],
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AOX1 Polyclonal Antibody
Ucallm_WP11058-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | AOX1 |
| Reactivity | Human, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 120kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AOX1. AA range:521-570 |
| Specificity | AOX1 Polyclonal Antibody detects endogenous levels of AOX1 protein. |
| Gene Name | AOX1 |
| Protein Name | Aldehyde oxidase |
| Other Name | AOX1; / AO; / Aldehyde oxidase |
| Species | Human |
| Gene ID | 316 |
| Uniprot | Q06278, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O54754, |
| Species.2 | Rat |
| Gene ID.2 | 54349 |
| Uniprot.2 | Q9Z0U5 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level). |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway |
| Research Areas | >>Valine, leucine and isoleucine degradation; / >>Tyrosine metabolism; / >>Tryptophan metabolism; / >>Vitamin B6 metabolism; / >>Nicotinate and nicotinamide metabolism; / >>Retinol metabolism; / >>Drug metabolism - cytochrome P450; / >>Metabolic pathways; / >>JAK-STAT signaling pathway |
| Function | Catalytic activity:An aldehyde + H(2)O + O(2) = a carboxylic acid + H(2)O(2).,Caution:Was originally (PubMed:8248161) thought to be a xanthine dehydrogenase.,cofactor:Binds 2 2Fe-2S clusters.,cofactor:FAD.,cofactor:Molybdopterin.,similarity:Belongs to the xanthine dehydrogenase family.,similarity:Contains 1 2Fe-2S ferredoxin-type domain.,similarity:Contains 1 FAD-binding PCMH-type domain.,subunit:Homodimer.,tissue specificity:Abundant in liver, lower levels in lung, skeletal muscle, pancreas. Undetected in heart, brain and kidney., |
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