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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/ATG5 rabbit pAb
SKU: WP17658 Categories: ,

ATG5 rabbit pAb

Ucallm_WP17658-50

Price range: $268.00 through $328.00

SKU: WP17658-100
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Product details

Background:

The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015],

Specifications

Size50μL/100μL
TargetATG5
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)30kD
MW(Observed)51kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ATG5 AA range: 180-260
SpecificityThis antibody detects endogenous levels of Human,Mouse,Rat ATG5
Gene NameATG5 APG5L ASP
Protein NameATG5
Other NameAutophagy protein 5; / APG5-like; / Apoptosis-specific protein
SpeciesHuman
Gene ID9474
UniprotQ9H1Y0,
Species.1Mouse
Gene ID.111793
Uniprot.1Q99J83,
Species.2Rat
Gene ID.2
Uniprot.2Q3MQ06
Cellular LocalizationCytoplasm . Preautophagosomal structure membrane; Peripheral membrane protein. Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .
Tissue ExpressionUbiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Cell growth and death >> Ferroptosis;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Organismal Systems >> Aging >> Longevity regulating pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Research Areas>>Autophagy - other; / >>Mitophagy - animal; / >>Autophagy - animal; / >>Longevity regulating pathway; / >>Longevity regulating pathway - multiple species; / >>Ferroptosis; / >>NOD-like receptor signaling pathway; / >>RIG-I-like receptor signaling pathway; / >>Shigellosis
FunctionFunction:May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.,Function:Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed.,induction:By apoptotic stimuli.,PTM:Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.,similarity:Belongs to the ATG5 family.,subcellular location:Colocalizes with nonmuscle actin.,tissue specificity:Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.,
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