Price range: $268.00 through $328.00
Background:
This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013],
| Size | 50μL/100μL |
| Target | Cytochrome c1 |
| Reactivity | Human, Mouse |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 35kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF/ICC1:100-500; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CYC1. AA range:132-181 |
| Specificity | Cytochrome c1 Polyclonal Antibody detects endogenous levels of Cytochrome c1 protein. |
| Gene Name | CYC1 |
| Protein Name | Cytochrome c1 heme protein mitochondrial |
| Other Name | CYC1; / Cytochrome c1; / heme protein, mitochondrial; / Complex III subunit 4; / Complex III subunit IV; / Cytochrome b-c1 complex subunit 4; / Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit; / Cytochrome c-1 |
| Species | Human |
| Gene ID | 1537 |
| Uniprot | P08574, |
| Species.1 | Mouse |
| Gene ID.1 | 66445 |
| Uniprot.1 | Q9D0M3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion inner membrane; Single-pass membrane protein . |
| Tissue Expression | Brain,Kidney,Lung,Skin, |
| Signaling_pathway | Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Oxidative phosphorylation; / >>Metabolic pathways; / >>Cardiac muscle contraction; / >>Thermogenesis; / >>Non-alcoholic fatty liver disease; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Chemical carcinogenesis - reactive oxygen species; / >>Diabetic cardiomyopathy |
| Function | Function:This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.,PTM:Binds 1 heme group per subunit.,similarity:Belongs to the cytochrome c family.,subunit:The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)., |
