Price range: $268.00 through $328.00
Background:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],
| Size | 50μL/100μL |
| Target | FRA1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 43kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FRA1. AA range:101-150 |
| Specificity | FRA1 Polyclonal Antibody detects endogenous levels of Fra-1 protein. |
| Gene Name | FOSL1 |
| Protein Name | Fos-related antigen 1 |
| Other Name | FOSL1; / FRA1; / Fos-related antigen 1; / FRA-1 |
| Species | Human |
| Gene ID | 8061 |
| Uniprot | P15407, |
| Species.1 | Mouse |
| Gene ID.1 | 14283 |
| Uniprot.1 | P48755, |
| Species.2 | Rat |
| Gene ID.2 | 25445 |
| Uniprot.2 | P10158 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Blood,Endothelial cell,Kidney,Skin, |
| Signaling_pathway | Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway |
| Research Areas | >>Wnt signaling pathway; / >>Osteoclast differentiation; / >>IL-17 signaling pathway; / >>Human T-cell leukemia virus 1 infection |
| Function | similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Fos subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer., |
