SKU: WP15739 Categories: ,

GABARAP Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15739-100
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Product details

Background:

function:Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the MAP1 LC3 family., subunit:Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1., tissue specificity:Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.,

Specifications

Size50μL/100μL
TargetGABARAPL2
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)17kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:10000-20000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthetic Peptide of GABARAP AA range: 26-75
SpecificityGABARAP Polyclonal Antibody detects endogenous levels of GABARAP
Gene NameGABARAPL2 FLC3A GEF2
Protein NameGABARAP
Other NameGABA; / A; / receptor-associated protein-like 2
SpeciesHuman
Gene ID11345
UniprotP60520,
Species.1Mouse
Gene ID.193739
Uniprot.1P60521,
Species.2Rat
Gene ID.2
Uniprot.2P60522
Cellular LocalizationCytoplasmic vesicle, autophagosome . Endoplasmic reticulum membrane . Golgi apparatus .
Tissue ExpressionUbiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
Research Areas>>FoxO signaling pathway; / >>Autophagy - other; / >>Mitophagy - animal; / >>Autophagy - animal; / >>NOD-like receptor signaling pathway; / >>GABAergic synapse
FunctionFunction:Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MAP1 LC3 family.,subunit:Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1.,tissue specificity:Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.,
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