Price range: $268.00 through $328.00
Background:
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | GABARAP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 13kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GBRAP AA range: 8-58 |
| Specificity | This antibody detects endogenous levels of GBRAP at Human/Mouse/Rat |
| Gene Name | GABARAP FLC3B HT004 |
| Protein Name | GBRAP |
| Other Name | |
| Species | Human |
| Gene ID | 11337 |
| Uniprot | O95166, |
| Species.1 | Mouse |
| Gene ID.1 | 56486 |
| Uniprot.1 | Q9DCD6, |
| Species.2 | Rat |
| Gene ID.2 | 58974 |
| Uniprot.2 | P60517 |
| Cellular Localization | Cytoplasmic vesicle, autophagosome membrane . Endomembrane system . Cytoplasm, cytoskeleton . Golgi apparatus membrane . Cytoplasmic vesicle . Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). . |
| Tissue Expression | Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway |
| Research Areas | >>FoxO signaling pathway; / >>Autophagy - other; / >>Mitophagy - animal; / >>Autophagy - animal; / >>NOD-like receptor signaling pathway; / >>GABAergic synapse |
| Function | Function:May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.,similarity:Belongs to the MAP1 LC3 family.,subcellular location:Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules.,subunit:Interacts with GPHN and NSF (By similarity). Interacts with GABRG2, beta-tubulin and ULK1.,tissue specificity:Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas., |
