Name: IRF-1 Polyclonal Antibody
SKU: WP15651
Price: 268 USD
Availability: InStock

IRF-1 Polyclonal Antibody

Ucallm_WP15651-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15651-100

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Product details

Background:

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	IRF-1
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA, IHC
MW(Calculated)
MW(Observed)	36kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human IRF1. AA range:91-140
Specificity	IRF-1 Polyclonal Antibody detects endogenous levels of IRF-1 protein.
Gene Name	IRF1
Protein Name	Interferon regulatory factor 1
Other Name	IRF1; / Interferon regulatory factor 1; / IRF-1
Species	Human
Gene ID	3659
Uniprot	P10914,
Species.1	Mouse
Gene ID.1	16362
Uniprot.1	P15314,
Species.2	Rat
Gene ID.2	24508
Uniprot.2	P23570
Cellular Localization	Nucleus . Cytoplasm . MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1. .
Tissue Expression	Pancreas,Placenta,Spleen,
Signaling_pathway	Organismal Systems >> Endocrine system >> Prolactin signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Research Areas	>>C-type lectin receptor signaling pathway; / >>TNF signaling pathway; / >>Prolactin signaling pathway; / >>Pertussis; / >>Human papillomavirus infection
Function	Disease:Deletion or rearrangement of IRF1 are a cause of preleukemic myelodysplastic syndrome (MDS) and of acute myelogenous leukemia (AML).,Function:Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor.,induction:By viruses and IFN.,PTM:Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites.,PTM:Ubiquitinated. Appears to compete with sumoylation on C-terminal sites.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,