SKU: WP1501 Categories: ,

KCNB2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1501-100
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Product details

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetKCNB2
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)100kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 170-250
SpecificityKCNB2 Polyclonal Antibody detects endogenous levels of protein.
Gene NameKCNB2
Protein NamePotassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)
Other Name
SpeciesHuman
Gene ID9312
UniprotQ92953,
Species.1Mouse
Gene ID.1
Uniprot.1A6H8H5,
Species.2Rat
Gene ID.2
Uniprot.2Q63099
Cellular LocalizationCell membrane; Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons. .
Tissue ExpressionBrain,
Signaling_pathway
Research Areas
FunctionDomain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,Function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.,PTM:Phosphorylated .,similarity:Belongs to the potassium channel family. B (Shab) subfamily.,subunit:Heteromultimer with KCNS1, KCNS2 and KCNS3.,
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