Price range: $268.00 through $328.00
Background:
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including extracellular matrix organization; prostate gland morphogenesis; and regulation of epithelial cell proliferation. Located in cytoplasm. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
| Size | 50μL/100μL |
| Target | Maspin |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 42kD |
| MW(Observed) | 40kD |
| Host Species | Mouse |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR2150 |
| Immunogen | Synthesized peptide derived from human Maspin. AA range: 300-375 |
| Specificity | This antibody detects endogenous levels of Maspin protein. |
| Gene Name | SERPINB5 |
| Protein Name | Serpin B5 |
| Other Name | SERPINB5; / PI5; / Serpin B5; / Maspin; / Peptidase inhibitor 5; / PI-5 |
| Species | Human |
| Gene ID | 5268 |
| Uniprot | P36952, |
| Species.1 | Mouse |
| Gene ID.1 | 20724 |
| Uniprot.1 | P70124, |
| Species.2 | Rat |
| Gene ID.2 | 116589 |
| Uniprot.2 | P70564 |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Normal mammary epithelial cells. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> p53 signaling pathway;Human Diseases >> Cancer: overview >> MicroRNAs in cancer |
| Research Areas | >>p53 signaling pathway; / >>MicroRNAs in cancer |
| Function | Function:Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.,similarity:Belongs to the serpin family. Ov-serpin subfamily.,tissue specificity:Normal mammary epithelial cells., |
