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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/MFRP Polyclonal Antibody
SKU: WP16087 Categories: ,

MFRP Polyclonal Antibody

Ucallm_WP16087-50

Price range: $268.00 through $328.00

SKU: WP16087-100
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Product details

Background:

membrane frizzled-related protein(MFRP) Homo sapiens This gene encodes a member of the frizzled-related protein family. The encoded protein plays an important role in eye development and mutations in this gene have been associated with nanophthalmos, posterior microphthalmia, retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic transcript which also encodes C1q and tumor necrosis factor related protein 5 (C1QTNF5). [provided by RefSeq, Jun 2013],

Specifications

Size50μL/100μL
TargetMFRP
ReactivityHuman, Mouse
ApplicationsIHC, IF, WB
MW(Calculated)
MW(Observed)62kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:50-200; WB 1:500-2000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human MFRP
SpecificityThis antibody detects endogenous levels of human MFRP
Gene NameMFRP
Protein NameMFRP
Other NameMembrane frizzled-related protein; / Membrane-type frizzled-related protein
SpeciesHuman
Gene ID114902
UniprotQ9BY79
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationApical cell membrane; Single-pass type II membrane protein .
Tissue ExpressionSpecifically expressed in brain. Strongly expressed in medulla oblongata and to a lower extent in hippocampus and corpus callosum. Expressed in keratinocytes.
Signaling_pathway
Research Areas
Functiondevelopmental stage:Expressed in fetal brain.,Disease:Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD) [MIM:605670]. LORD is an autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy.,Disease:Defects in MFRP are the cause of microphthalmia MFRP-related (MCOPMFRP) [MIM:611040]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. MCOPMFRP is characterized by posterior microphthalmia, retinitis pigmentosa, foveoschisis and optic disc drusen.,Disease:Defects in MFRP are the cause of nanophthalmos 2 (NNO2) [MIM:609549]. NNO2 is a rare autosomal recessive disorder of eye development characterized by extreme hyperopia and small functional eyes.,Function:May play a role in eye development.,similarity:Contains 1 C1q domain.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 LDL-receptor class A domains.,tissue specificity:Specifically expressed in brain. Strongly expressed in medulla oblongata and to a lower extent in hippocampus and corpus callosum. Expressed in keratinocytes.,
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