MMP8 (Cleaved-Leu101) rabbit pAb
Ucallm_WP0183-50
Price range: $268.00 through $328.00
Product details
Background:
catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I., cofactor:Binds 2 zinc ions per subunit., cofactor:Binds 3 calcium ions per subunit., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., enzyme regulation:Cannot be activated without removal of the activation peptide., function:Can degrade fibrillar type I, II, and III collagens., similarity:Belongs to the peptidase M10A family., similarity:Contains 4 hemopexin-like domains., subcellular location:Stored in intracellular granules., tissue specificity:Neutrophils.,
Specifications
| Size | 50μL/100μL |
| Target | MMP-8 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| MW(Calculated) | |
| MW(Observed) | 40kD,53kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MMP8 (Cleaved-Leu101) |
| Specificity | This antibody detects endogenous levels of Human,Mouse,Rat MMP8 (Cleaved-Leu101, protein was cleaved amino acid sequence between 100-101 ) |
| Gene Name | MMP8 CLG1 |
| Protein Name | MMP8 (Cleaved-Leu101) |
| Other Name | MMP8; / CLG1; / Neutrophil collagenase; / Matrix metalloproteinase-8; / MMP-8; / PMNL collagenase; / PMNL-CL |
| Species | Human |
| Gene ID | 4317 |
| Uniprot | P22894, |
| Species.1 | Mouse |
| Gene ID.1 | 17394 |
| Uniprot.1 | O70138, |
| Species.2 | Rat |
| Gene ID.2 | 63849 |
| Uniprot.2 | O88766 |
| Cellular Localization | Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Stored in intracellular granules. |
| Tissue Expression | Neutrophils. |
| Signaling_pathway | |
| Research Areas | |
| Function | skeletal system development, ossification, proteolysis, collagen catabolic process, collagen metabolic process,multicellular organismal metabolic process, multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process, bone development, |
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