SKU: WP2930 Categories: ,

SSR3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2930-100
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Product details

Background:

This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Specifications

Size50μL/100μL
TargetSSR3
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)45kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 340-420
SpecificitySSR3 Polyclonal Antibody detects endogenous levels of protein.
Gene NameSSTR3
Protein NameSomatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SSR-28)
Other Name
SpeciesHuman
Gene ID6753
UniprotP32745,
Species.1Mouse
Gene ID.1
Uniprot.1P30935,
Species.2Rat
Gene ID.2
Uniprot.2P30936
Cellular LocalizationCell membrane; Multi-pass membrane protein . Internalized into endoplasmic vesicles upon somatostatin-stimulation. .
Tissue ExpressionBrain, pituitary and pancreas.
Signaling_pathwayOrganismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action
Research Areas>>Neuroactive ligand-receptor interaction; / >>Growth hormone synthesis, secretion and action
FunctionFunction:Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.,PTM:Phosphorylated. Phosphorylation increases upon somatostatin binding.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Internalized into endoplasmic vesicles upon somatostatin-stimulation.,tissue specificity:Brain, pituitary and pancreas.,
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