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SSR5 Polyclonal Antibody
Ucallm_WP2931-50
Price range: $268.00 through $328.00
Product details
Background:
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010],
Specifications
| Size | 50μL/100μL |
| Target | SSR5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 270-350 |
| Specificity | SSR5 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SSTR5 |
| Protein Name | Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) |
| Other Name | |
| Species | Human |
| Gene ID | 6755 |
| Uniprot | P35346, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O08858, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P30938 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Growth hormone synthesis, secretion and action |
| Function | Function:Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary., |
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