Product details
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TRMT10C rabbit pAb
Ucallm_WP8654-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TRMT10C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 44kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRMT10C |
| Specificity | This antibody detects endogenous levels of TRMT10C at Human, Mouse,Rat |
| Gene Name | TRMT10C MRPP1 RG9MTD1 |
| Protein Name | Mitochondrial ribonuclease P protein 1 (Mitochondrial RNase P protein 1) (HBV pre-S2 trans-regulated protein 2) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (tRNA methyltransferase 10 homolog C) |
| Other Name | |
| Species | Human |
| Gene ID | 54931 |
| Uniprot | Q7L0Y3, |
| Species.1 | Mouse |
| Gene ID.1 | 52575 |
| Uniprot.1 | Q3UFY8, |
| Species.2 | Rat |
| Gene ID.2 | 304012 |
| Uniprot.2 | Q5U2R4 |
| Cellular Localization | Mitochondrion matrix, mitochondrion nucleoid . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation . Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends . Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity . The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit . The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme . In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA . Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. |
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