Name: TrxR2 Polyclonal Antibody
SKU: WP14871
Price: 268 USD
Availability: InStock

TrxR2 Polyclonal Antibody

Ucallm_WP14871-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP14871-100

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Product details

Background:

thioredoxin reductase 2(TXNRD2) Homo sapiens This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013],

Specifications

Size	50μL/100μL
Target	TXNRD2
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	56kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human TRXR2. AA range:471-520
Specificity	TrxR2 Polyclonal Antibody detects endogenous levels of TrxR2 protein.
Gene Name	TXNRD2
Protein Name	Thioredoxin reductase 2 mitochondrial
Other Name	TXNRD2; / KIAA1652; / TRXR2; / Thioredoxin reductase 2; / mitochondrial; / Selenoprotein Z; / SelZ; / TR-beta; / Thioredoxin reductase TR3
Species	Human
Gene ID	10587
Uniprot	Q9NNW7,
Species.1	Mouse
Gene ID.1	26462
Uniprot.1	Q9JLT4,
Species.2	Rat
Gene ID.2	50551
Uniprot.2	Q9Z0J5
Cellular Localization	Mitochondrion .
Tissue Expression	Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690).
Signaling_pathway	Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma
Research Areas	>>Selenocompound metabolism; / >>Pathways in cancer; / >>Hepatocellular carcinoma
Function	Catalytic activity:Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.,cofactor:FAD.,Function:Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.,miscellaneous:The active site is a redox-active disulfide bond. The selenocysteine residue is essential for enzymatic activity.,sequence Caution:Translated as Sec.,similarity:Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.,subunit:Homodimer.,tissue specificity:Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614 levels are low.,