Cytoplasm, cytosol . Nucleus . Predominantly cytosolic. Some fraction is nuclear. .
Tissue Expression
Signaling_pathway
Research Areas
Function
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.