Product details
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TIMELESS rabbit pAb
Ucallm_WP6787-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TIMELESS |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 133kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TIMELESS |
| Specificity | This antibody detects endogenous levels of TIMELESS at Human, Mouse,Rat |
| Gene Name | TIMELESS TIM TIM1 TIMELESS1 |
| Protein Name | Protein timeless homolog (hTIM) |
| Other Name | |
| Species | Human |
| Gene ID | 8914 |
| Uniprot | Q9UNS1, |
| Species.1 | Mouse |
| Gene ID.1 | 21853 |
| Uniprot.1 | Q9R1X4, |
| Species.2 | Rat |
| Gene ID.2 | 83508 |
| Uniprot.2 | Q9Z2Y1 |
| Cellular Localization | Nucleus . Chromosome . In response to double-strand breaks (DSBs), accumulates at DNA damage sites via its interaction with PARP1. . |
| Tissue Expression | Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock . Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress . TIMELESS promotes TIPIN nuclear localization . Involved in cell survival after DNA damage or replication stress by promoting DNA repair . In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 . May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light . Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock . Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus . May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). |
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