SKU: WP11185 Categories: ,

ATF-3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11185-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

activating transcription factor 3(ATF3) Homo sapiens This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011],

Specifications

Size50μL/100μL
TargetATF-3
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)22kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:100-500; IF/ICC1:100-500; ELISA 1:5000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human ATF3. AA range:131-180
SpecificityATF-3 Polyclonal Antibody detects endogenous levels of ATF-3 protein.
Gene NameATF3
Protein NameCyclic AMP-dependent transcription factor ATF-3
Other NameATF3; / Cyclic AMP-dependent transcription factor ATF-3; / cAMP-dependent transcription factor ATF-3; / Activating transcription factor 3
SpeciesHuman
Gene ID467
UniprotP18847,
Species.1Mouse
Gene ID.111910
Uniprot.1Q60765,
Species.2Rat
Gene ID.225389
Uniprot.2P29596
Cellular LocalizationNucleus .
Tissue ExpressionAmygdala,Brain,Cerebellum,Muscle,
Signaling_pathway
Research Areas
FunctionFunction:This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a homodimer or a heterodimer.,
Please login to post questions
Back to Top
Product has been added to your cart