Price range: $268.00 through $328.00
Background:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013],
| Size | 50μL/100μL |
| Target | IRK15 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 41kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 30-110 |
| Specificity | IRK15 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | KCNJ15 KCNJ14 |
| Protein Name | ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir1.3) (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15) |
| Other Name | |
| Species | Human |
| Gene ID | 3772 |
| Uniprot | Q99712, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O88932, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q91ZF1 |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Expression | Kidney, |
| Signaling_pathway | |
| Research Areas | >>Gastric acid secretion |
| Function | Function:Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Interacts with INADL., |
