Price range: $268.00 through $328.00
Background:
This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011],
| Size | 50μL/100μL |
| Target | SPZ1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 133kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SPZ1. AA range:111-160 |
| Specificity | SPZ1 Polyclonal Antibody detects endogenous levels of SPZ1 protein. |
| Gene Name | SPZ1 |
| Protein Name | Spermatogenic leucine zipper protein 1 |
| Other Name | SPZ1; / TSP1; / Spermatogenic leucine zipper protein 1; / Testis-specific protein 1; / Testis-specific protein NYD-TSP1 |
| Species | Human |
| Gene ID | 84654 |
| Uniprot | Q9BXG8, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99MY0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | Specifically and strongly expressed in the testis. Expressed in several tumor cell lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis.,PTM:Phosphorylated by ERK1 and ERK2.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Interacts with PPP1CC isoform gamma-2.,tissue specificity:Specifically and strongly expressed in the testis. Expressed in several tumor cell lines., |
