Name: Tropomyosin α Polyclonal Antibody
SKU: WP14865
Price: 268 USD
Availability: InStock

Tropomyosin α Polyclonal Antibody

Ucallm_WP14865-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP14865-100

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Product details

Background:

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by

Specifications

Size	50μL/100μL
Target	Tropomyosin α
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	35kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human Tropomyosin alpha. AA range:40-89
Specificity	Tropomyosin α Polyclonal Antibody detects endogenous levels of Tropomyosin α protein.
Gene Name	TPM1
Protein Name	Tropomyosin alpha-1 chain
Other Name	TPM1; / C15orf13; / TMSA; / Tropomyosin alpha-1 chain; / Alpha-tropomyosin; / Tropomyosin-1
Species	Human
Gene ID	7168
Uniprot	P09493,
Species.1	Mouse
Gene ID.1	22003
Uniprot.1	P58771,
Species.2	Rat
Gene ID.2	24851
Uniprot.2	P04692
Cellular Localization	Cytoplasm, cytoskeleton . Associates with F-actin stress fibers. .
Tissue Expression	Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.
Signaling_pathway	Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Human Diseases >> Cancer: overview >> MicroRNAs in cancer
Research Areas	>>Cardiac muscle contraction; / >>Adrenergic signaling in cardiomyocytes; / >>MicroRNAs in cancer; / >>Hypertrophic cardiomyopathy; / >>Dilated cardiomyopathy
Function	Alternative products:Additional isoforms seem to exist,Disease:Defects in TPM1 are the cause of cardiomyopathy dilated type 1Y (CMD1Y) [MIM:611878]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,Disease:Defects in TPM1 are the cause of cardiomyopathy familial hypertrophic type 3 (CMH3) [MIM:115196]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,Domain:The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.,Function:Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.,mass spectrometry: PubMed:11840567,similarity:Belongs to the tropomyosin family.,subunit:Heterodimer of an alpha and a beta chain.,tissue specificity:Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.,