Price range: $268.00 through $328.00
Background:
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],
| Size | 50μL/100μL |
| Target | TKT |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 68kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein AA range: 125-175 |
| Specificity | TKT Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TKT |
| Protein Name | Transketolase (TK) (EC 2.2.1.1) |
| Other Name | |
| Species | Human |
| Gene ID | 7086 |
| Uniprot | P29401, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P40142, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P50137 |
| Cellular Localization | nucleus,nucleoplasm,peroxisome,cytosol,vesicle,myelin sheath,extracellular exosome, |
| Tissue Expression | Brain,Epithelium,Human uterus,Kidney,Liver,Lymph,Platelet,Thymus, |
| Signaling_pathway | |
| Research Areas | >>Pentose phosphate pathway; / >>Metabolic pathways; / >>Carbon metabolism; / >>Biosynthesis of amino acids |
| Function | Catalytic activity:Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.,cofactor:Binds 1 calcium ion per subunit.,cofactor:Binds 1 thiamine pyrophosphate per subunit.,Disease:Has been implicated in the latent genetic disease Wernicke-Korsakoff syndrome (WKS) [MIM:277730]. WKS causes specific brain damage.,online information:Transketolase entry,similarity:Belongs to the transketolase family.,subunit:Homodimer., |
