Product details
Background:
- Please choose product options by visiting TRPC1 Polyclonal Antibody.
- Please choose product options by visiting TRIOBP rabbit pAb.
- Please choose product options by visiting Trk A (phospho Tyr496) Polyclonal Antibody.
- Please choose product options by visiting TRI44 rabbit pAb.
- Please choose product options by visiting TRI47 rabbit pAb.
- Please choose product options by visiting TRIM29 rabbit pAb.
- Please choose product options by visiting TRI10 rabbit pAb.
- Please choose product options by visiting TRI17 rabbit pAb.
- Please choose product options by visiting TRMT10A rabbit pAb.
- Please choose product options by visiting TRMT10C rabbit pAb.
- Please choose product options by visiting TRMT61B rabbit pAb.
TRIM8 rabbit pAb
Ucallm_WP6909-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TRIM8 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 61kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRIM8 |
| Specificity | This antibody detects endogenous levels of TRIM8 at Human, Mouse |
| Gene Name | TRIM8 GERP RNF27 |
| Protein Name | Probable E3 ubiquitin-protein ligase TRIM8 (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (Tripartite motif-containing protein 8) |
| Other Name | |
| Species | Human |
| Gene ID | 81603 |
| Uniprot | Q9BZR9, |
| Species.1 | Mouse |
| Gene ID.1 | 93679 |
| Uniprot.1 | Q99PJ2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B. . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response . Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 . Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B . Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus . Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction . |
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