Product details
Background:
- Please choose product options by visiting TRPC1 Polyclonal Antibody.
- Please choose product options by visiting TRIOBP rabbit pAb.
- Please choose product options by visiting Trk A (phospho Tyr496) Polyclonal Antibody.
- Please choose product options by visiting TRI44 rabbit pAb.
- Please choose product options by visiting TRI47 rabbit pAb.
- Please choose product options by visiting TRIM29 rabbit pAb.
- Please choose product options by visiting TRI10 rabbit pAb.
- Please choose product options by visiting TRI17 rabbit pAb.
- Please choose product options by visiting TRMT10A rabbit pAb.
- Please choose product options by visiting TRMT10C rabbit pAb.
- Please choose product options by visiting TRMT61B rabbit pAb.
- Please choose product options by visiting TRIM8 rabbit pAb.
TRIM39 rabbit pAb
Ucallm_WP8610-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TRIM39 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 57kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRIM39 |
| Specificity | This antibody detects endogenous levels of TRIM39 at Human, Mouse,Rat |
| Gene Name | TRIM39 RNF23 TFP |
| Protein Name | E3 ubiquitin-protein ligase TRIM39 (RING finger protein 23) (Testis-abundant finger protein) (Tripartite motif-containing protein 39) |
| Other Name | |
| Species | Human |
| Gene ID | 56658 |
| Uniprot | Q9HCM9, |
| Species.1 | Mouse |
| Gene ID.1 | 79263 |
| Uniprot.1 | Q9ESN2, |
| Species.2 | Rat |
| Gene ID.2 | 309591 |
| Uniprot.2 | Q6MFZ5 |
| Cellular Localization | [Isoform 1]: Cytoplasm, cytosol . Mitochondrion . Nucleus . Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. .; [Isoform 2]: Nucleus . Colocalizes with CDKN1A in the nucleus. . |
| Tissue Expression | Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | [Isoform 1]: E3 ubiquitin-protein ligase . May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 . Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation .; [Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner . |
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